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Gambelia is a genus of lizards, commonly known as leopard lizards, within the family Crotaphytidae. Leopard lizards are indigenous to arid environments of southwestern North America.
Species in the genus Gambelia superficially resemble those of the genus Crotaphytus. However, one difference between the genera Gambelia and Crotaphytus is that leopard lizards have fracture planes in their tails, allowing the tails to break off when grasped by predators.